Discovery and mechanistic characterization of selective inhibitors of H2S-producing enzyme: 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide.

Hanaoka, K., Sasakura, K., Suwanai, Y., Toma-Fukai, S., Shimamoto, K., Takano, Y., Shibuya, N., Terai, T., Komatsu, T., Ueno, T., Ogasawara, Y., Tsuchiya, Y., Watanabe, Y., Kimura, H., Wang, C., Uchiyama, M., Kojima, H., Okabe, T., Urano, Y., Shimizu, T., Nagano, T.

Sci. Rep.

2017/01

7

40227

paper